New Snags Develop Over Access to Nixon Papers

John Alexander Nixon

Methods extends free access to papers and offers optional open access model: new services and opportunities for authors and readers .

R. Haux1; D. Aronsky2; T. Y. Leong3; A. T. McCray4 1 University of Braunschweig – Institute of Technology and Hannover Medical School, Braunschweig, Germany; 2 Vanderbilt University, Department of Biomedical Informatics and Emergency Medicine, Nashville, Tennessee, USA; 3 National University of Singapore, Department of Computer Science, Singapore; 4 Harvard University, Center for Biomedical Inf...

Amended Snags article

1 The unusual behavior during purification of four affinity-tagged proteins—a MAP kinase, a transcription factor, intracellular binding protein, and a receptor tyrosine kinase—led the authors to devise alternate methods of obtaining their end-product. They found it necessary to either remove the affinity tag (by recloning or by cleavage of the tag) or omit the traditional immobilized metal ion ...

Antibody engineering to develop new antirheumatic therapies

There has been a therapeutic revolution in rheumatology over the past 15 years, characterised by a move away from oral immuno-suppressive drugs toward parenteral targeted biological therapies. The potency and relative safety of the newer agents has facilitated a more aggressive approach to treatment, with many more patients achieving disease remission. There is even a prevailing sense that dise...

Using New Standards to Develop IC Ontologies

In this paper we describe recent work in adapting various new OWL and ontology standards to ontology development for the IC and DoD. We present work done to adapt the Universal Core Semantic Layer (UCore SL) standard ontology to support intelligence analysts. We show how new features in the OWL 2 standard can be used to make such ontologies simpler and more readable, and how they facilitate mod...